Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides
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چکیده
منابع مشابه
Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides
Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a-p are reported. The test compounds 6a-p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 636 μ mol/kg in the scPTZ screen without any neurotoxicity. The assigned (E)-configuration of the t...
متن کاملExperimental and Theoretical Studies of the Vibrational and Electronic Properties of (2E)-2-[3-(1H-imidazol-1-yl)-1-phenyl-propylidene]-N-phenylhydrazinecarboxamide: An Anticonvulsant Agent
In the current investigation, the molecular structure of the anticonvulsant agent (2E)-2-[3-(1H-imidazol-1-yl)-1-phenylpropylidene]-N-phenylhydrazinecarboxamide ((2E)-HIPC) was theoretically modelled using ab initio Hartree-Fock (HF) and density functional theory (DFT/B3LYP) calculations. The Fourier transform (FT) infrared and FT-Raman spectra of (2E)-HIPC were also recorded, and the observed ...
متن کامل{N-[1-(1H-Benzimidazol-2-yl)ethylidene-κN 3]-3-(1H-imidazol-1-yl)propan-1-amine-κN}dibromidomercury(II)
In the title compound, [HgBr(2)(C(15)H(17)N(5))], the Hg(II) ion is tetra-hedrally coordinated by two N atoms of the N-[1-(1H-benzimidazol-2-yl)ethyl-idene-κN]-3-(1H-imidazol-1-yl)propan-1-amine ligand, and two bromide anions. Inter-molecular benzimidazole-imidazole N-H⋯N hydrogen bonds link the mol-ecules into helical chains along the b-axis direction and C-H⋯Br hydrogen bonds link these chain...
متن کامل(2E)-2-[(2E)-3-Phenylprop-2-en-1-ylidene]-2,3-dihydro-1H-inden-1-one
The title indan-1-one derivative, C(18)H(14)O, is planar with an r.m.s. deviation for all 19 non-H atoms of 0.098 Å. The conformation about each of the C=C bonds [1.343 (3) and 1.349 (3) Å] is E. Supra-molecular layers in the bc plane, mediated by C-H⋯O and π-π [ring centroid-centroid distance = 3.5282 (15) Å] inter-actions, feature in the crystal packing.
متن کامل1-Aryl-3-(1H-imidazol-1-yl)propan-1-ol esters: synthesis, anti-Candida potential and molecular modeling studies
BACKGROUND An increased incidence of fungal infections, both invasive and superficial, has been witnessed over the last two decades. Candida species seem to be the main etiology of nosocomial fungal infections worldwide with Candida albicans, which is commensal in healthy individuals, accounting for the majority of invasive Candida infections with about 30-40% of mortality. RESULTS New aromat...
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ژورنال
عنوان ژورنال: The Scientific World Journal
سال: 2014
ISSN: 2356-6140,1537-744X
DOI: 10.1155/2014/357403